I see where you're coming from.
I think the article was referring to modifying the engine with higher compression and higher pressure (DI) & increased volume of fuel charge to get the most out of the E -85 energy content. For instance, if you tune for E-85 exclusively, you get better performance and fuel economy vs Chevy Flex Fuel pickups where they have to compromise between fuel types, and assume that the owner is more likely to use E-10 regular octane vs E-85.
I do understand the issue with low fuel pressures due to DIFP limitations and it's effect, l but as you know, I experienced high combustion pressure issues due to my stupidity... Was relating this to our engines if one could get the amount of fuel that the article said was desirable. From that standpoint I thought the article was a bit confusing and didn't explain why as thoroughly as I would have liked, especially when they were comparing it to Diesel engine specs.
My only concern for you is that you will be adding quite a bit of new fuel and NO. Just not sure when you will reach the maximum safe amount that the current rods and pistons can handle. What I did was add a great deal of a product that was less combustible at a low RPM, without realizing what I was doing.